Just over two years http://couponbuymdcost.top/maps/sitemap9.html generic viagra cialis uk The use of hormone therapy -- both estrogen-only and the combination of estrogen plus progestin -- declined greatly after the U.S. Women's Health Initiative Study found in 2002 that combination therapy had ill effects, including an increase in breast cancer, heart disease, stroke and blood clots. Prescriptions for both regimens plummeted even though the research didn't apply to women without a uterus or to women on estrogen-only therapy, said Sarrel, who is a consultant for Noven Therapeutics, which makes an estrogen patch.