I've only just arrived <a href=" http://www.moda-inc.com/imipramine-sigma.pdf#protect ">tofranil used for bedwetting</a> In the first study, scientists at the Universities of Bristol and Lincoln and the Food and Environment Research Agency, concluded that the use of e-collars &ldquo;can lead to a negative impact on welfare at least in a proportionate of animals trained using this technique&rdquo;. It also found that a large number of owners using the devices did so without adhering to the accompanying instruction manuals.